As explained in part 1, joint space width is a crucial parameter. Condylar displacement and joint space narrowing in the sense of compression can be treated effectively with aligner therapy. In addition to scans, a digital temporomandibular joint analysis is required. In this temporomandibular joint analysis, the present authors determine a precise new physiological condylar position and the rotation axis and transfer both to virtual treatment simulation software. The virtual treatment begins with the mounting of the mandible to the maxilla in the exact condylar position. The individual virtual tooth movements are performed by moving the mandible along the patient’s specific rotation axis. The same procedure is also applied to patients without temporomandibular disorder, in which case the condylar position is not changed.